세계의 마이크로 RNA (miRNA) 시장 2024-2030 : 기기, 소모품

■ 영문 제목 : MicroRNA Market Size, Share & Trends Analysis Report By Products & Services (Instruments, Consumables), By Application (Cancer, Infectious Diseases) By End-use, By Region, And Segment Forecasts, 2024 - 2030

Grand View Research가 발행한 조사보고서이며, 코드는 GRV24JNU059 입니다.■ 상품코드 : GRV24JNU059
■ 조사/발행회사 : Grand View Research
■ 발행일 : 2023년 12월
■ 페이지수 : 120
■ 작성언어 : 영어
■ 보고서 형태 : PDF
■ 납품 방식 : E메일
■ 조사대상 지역 : 세계
■ 산업 분야 : 바이오
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글로벌 마이크로 RNA (miRNA) 시장의 성장과 동향
Grand View Research, Inc.사의 최신 보고서에 따르면, 세계의 마이크로 RNA (miRNA) 시장 규모는 2024년부터 2030년까지 12.87%의 CAGR을 기록하며 2030년까지 36.4억 달러에 달할 것으로 예측됩니다. 새로운 진단 검사 및 치료제 개발을 위한 R&D 이니셔티브에 대한 막대한 투자와 임상 시험에서 마이크로 RNA (miRNA)의 성공적인 통합이 이 시장의 성장을 주도하고 있습니다. 현재 생명공학 산업에서 바이오 의약품 부문은 중요한 역할을 하고 있으며, 생명공학 산업에서 연구개발에 대한 지출이 크게 증가하고 있습니다. 일부 바이오 제약 회사는 RNA 기반 치료제(miRNA 및 siRNA) 개발에 투자하고 있습니다. 주요 기업으로는 Regulus Therapeutics, Rosetta Genomics, Alnylam Pharmaceuticals, miRagen Therapeutics, Mirna Therapeutics 등이 있습니다.

새로운 진단 테스트 및 치료제 개발을 위한 miRNA 연구 개발 이니셔티브에 대한 정부 자금의 증가와 함께 막대한 투자가 시장 성장을 촉진할 것으로 예상됩니다. 표적치료제 개발 및 신약 타깃 발굴을 위한 혁신적인 접근 방식으로 시장에 진입한 신규 진입 기업들도 있습니다. 예를 들어, 2022년 4월 엘스비어(Elsevier)지에 게재된 논문에서 연구팀은 질병의 조기 진단을 위한 순환 miRNA의 임상적 가치를 보여주는 현재 대규모 코호트 연구의 요약을 제공합니다.

특히 흉부암과 같은 암 세포주에서 다양한 마이크로 RNA (miRNA)의 종양 억제 효과를 조사하는 연구가 증가함에 따라 마이크로 RNA (miRNA) 연구 도구에 대한 수요가 증가하고 있습니다. 또한, miRNA 기반 치료제는 다양한 질병 치료에서 높은 잠재력을 보여주며 지속적으로 발전하고 있으며, miRNA 기반 치료제를 표적 세포에 정확하게 전달하는 것은 여전히 임상 적용에 있어 큰 도전 과제입니다. 그러나 최근 나노입자 기반 전달 시스템과 같은 효율적인 전달 시스템의 도입은 이 문제를 극복하는 데 도움이 될 것으로 기대되고 있습니다.

마이크로 RNA (miRNA) 시장 보고서 주요 내용

- 제품 및 서비스별로는 분리 및 정제, miRNA cDNA 합성, 프로파일링, 국소화, 정량화, 기능 분석 등 다양한 서비스를 제공할 수 있는 서비스 분야가 2023년 58.8%의 높은 수익 점유율로 시장을 주도할 것으로 전망됩니다.

- 용도별로는 miRNA 시그니처를 활용한 암 연구에 대한 투자가 많아 2023년 암 분야가 가장 높은 매출 점유율을 차지할 것으로 예상됩니다.

- 최종 용도별로는 생명공학 및 제약 기업이 최첨단 연구에 대한 접근과 대규모 프로젝트에서 공동 연구를 가능하게 하는 연구 기관과의 공동 연구 및 파트너십을 구축할 수 있는 능력으로 인해 2023년 가장 높은 수익 점유율을 차지할 것으로 예상했습니다.

- 북미는 이 지역의 주요 시장 플레이어의 존재로 인해 2023년 세계 산업에서 우위를 차지할 것으로 보입니다.
■ 보고서 개요

1. 조사 방법 및 범위
2. 요약
3. 세계의 마이크로 RNA (miRNA) 시장 변수, 동향 및 범위
4. 세계의 마이크로 RNA (miRNA) 시장 규모 : 제품별 및 서비스 예측 및 동향 분석
5. 세계의 마이크로 RNA (miRNA) 시장 규모 : 용도별 예측 및 동향 분석
6. 세계의 마이크로 RNA (miRNA) 시장 규모 : 최종 용도별 예측 및 동향 분석
7. 세계의 마이크로 RNA (miRNA) 시장 규모 : 지역별 비즈니스 분석
8. 경쟁 현황

■ 보고서 목차

Table of Contents

Chapter 1. Methodology and Scope
1.1. Market Segmentation and Scope
1.1.1. Segment Definitions
1.1.1.1. Products & Service Segment
1.1.1.2. Application Segment
1.1.1.3. End-use Segment
1.2. Regional Scope
1.3. Estimates and Forecast Timeline
1.4. Objectives
1.4.1. Objective – 1
1.4.2. Objective – 2
1.5. Research Methodology
1.6. Information Procurement
1.6.1. Purchased Database
1.6.2. GVR’s Internal Database
1.6.3. Secondary Sources
1.6.4. Primary Research
1.7. Information or Data Analysis
1.7.1. Data Analysis Models
1.8. Market Formulation & Validation
1.9. Model Details
1.9.1. Commodity Flow Analysis
1.10. List of Primary Sources
1.11. List of Abbreviations
Chapter 2. MicroRNA (miRNA) Market: Executive Summary
2.1. Market Snapshot
2.2. Products and Services Snapshots
2.3. Application and End-use Snapshot
2.4. Competitive Landscape Snapshot
Chapter 3. MicroRNA (miRNA) Market Variables, Trends, & Scope
3.1. Market Segmentation and Scope
3.2. Market Lineage Outlook
3.2.1. Parent Market Outlook
3.2.2. Related/Ancillary Market Outlook
3.3. Market Dynamics
3.4. Market Drivers Analysis
3.4.1. Outbreak of COVID – 19
3.4.2. Recent innovation in application of miRNAs
3.4.2.1. Increased adoption for use as a biomarker
3.4.2.2. Therapeutic applications
3.4.3. High investments in miRNA R&D initiatives for development of new diagnostic tests & therapeutics
3.4.4. The success of miRNA in clinical trials
3.4.5. Technological advancements to support nucleic acid studies
3.4.6. Exponentially declining cost of sequencing
3.5. Market Restraint Analysis
3.5.1. High cost associated with microRNA kits and other products
3.5.2. Challenges in handling RNA & in-house development of assays for microRNA detection
3.5.3. Poor reproducibility of research and specificity of products
3.5.4. Limited life science research infrastructure in emerging markets
3.6. Business Environment Analysis
3.6.1. Porter’s Five Forces Analysis
3.6.2. PESTLE Analysis
3.7. COVID-19 Analysis
Chapter 4. Products & Services Estimates & Trend Analysis
4.1. MicroRNA (miRNA) Market: Products Movement Analysis
4.2. Instruments
4.2.1. Instruments Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.2. Technology
4.2.2.1. Technology Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.2.2. Real-Time PCR
4.2.2.2.1. Real-Time PCR Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.2.3. Microarray
4.2.2.3.1. Microarray Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.2.4. NGS
4.2.2.4.1. NGS Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.2.5. Others
4.2.2.5.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3. Workflow
4.2.3.1. Workflow Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3.2. Isolation & Purification
4.2.3.2.1. Isolation & Purification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3.3. miRNA cDNA Synthesis
4.2.3.3.1. miRNA cDNA Synthesis Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3.4. Profiling, Localization, & Qualification
4.2.3.4.1. Profiling, Localization, & Qualification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3.5. Functional Analysis & Others
4.2.3.5.1. Functional Analysis & Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.2.3.6. Others
4.2.3.6.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3. Consumables
4.3.1. Consumables Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2. Specimen
4.3.2.1. Specimen Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.2. Whole Blood
4.3.2.2.1. Whole Blood Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.3. Serum
4.3.2.3.1. Serum Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.4. Plasma
4.3.2.4.1. Plasma Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.5. FFPE
4.3.2.5.1. FFPE Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.6. Fresh Frozen Tissue
4.3.2.6.1. Fresh Frozen Tissue Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.2.7. Others
4.3.2.7.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3. Workflow
4.3.3.1. Workflow Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3.2. Isolation & Purification
4.3.3.2.1. Isolation & Purification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3.3. miRNA cDNA Synthesis
4.3.3.3.1. miRNA cDNA Synthesis Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3.4. Profiling, Localization, & Qualification
4.3.3.4.1. Profiling, Localization, & Qualification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3.5. Functional Analysis & Others
4.3.3.5.1. Functional Analysis & Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.3.3.6. Others
4.3.3.6.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4. Services
4.4.1. Service Type Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4.2. Isolation & Purification
4.4.2.1. Isolation & Purification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4.3. miRNA cDNA Synthesis
4.4.3.1. miRNA cDNA Synthesis Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4.4. Profiling, Localization, & Qualification
4.4.4.1. Profiling, Localization, & Qualification Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4.5. Functional Analysis
4.4.5.1. Functional Analysis Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.4.6. Others
4.4.6.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5. Specimen
4.5.1. Specimen Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.2. Whole Blood
4.5.2.1. Whole Blood Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.3. Serum
4.5.3.1. Serum Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.4. Plasma
4.5.4.1. Plasma Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.5. FFPE
4.5.5.1. FFPE Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.6. Fresh Frozen Tissue
4.5.6.1. Fresh Frozen Tissue Market Estimates and Forecasts, 2018 – 2030 (USD Million)
4.5.7. Others
4.5.7.1. Others Market Estimates and Forecasts, 2018 – 2030 (USD Million)
Chapter 5. Application Estimates & Trend Analysis
5.1. MicroRNA (miRNA) Market: Application Movement Analysis
5.2. Cancer
5.2.1. Cancer Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
5.3. Infectious Diseases
5.3.1. Infectious Diseases Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
5.4. Immunological Disorder
5.4.1. Immunological Disorder Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
5.5. Cardiovascular Disease
5.5.1. Cardiovascular Disease Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
5.6. Neurological Disease
5.6.1. Neurological Disease Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
5.7. Others
5.7.1. Others Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
Chapter 6. End-use Estimates & Trend Analysis
6.1. MicroRNA (miRNA) Market: End-use Movement Analysis
6.2. Biotechnology & Pharmaceutical Companies
6.2.1. Biotechnology & Pharmaceutical Companies Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
6.3. Academic & Government Research Institutes
6.3.1. Academic & Government Research Institutes Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
6.4. Other End-users
6.4.1. Other End-users Market Revenue Estimates and Forecasts, 2018 – 2030 (USD Million)
Chapter 7. Regional Business Analysis
7.1. Regional Market Snapshot
7.2. North America
7.2.1. North America MicroRNA (miRNA) Market Estimates And Forecast, 2018 – 2030 (USD Million)
7.2.2. U.S.
7.2.2.1. Key Country Dynamics
7.2.2.2. Competitive Scenario
7.2.2.3. Regulatory Framework
7.2.2.4. Target Disease Prevalence
7.2.2.5. U.S. MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.2.3. Canada
7.2.3.1. Key Country Dynamics
7.2.3.2. Competitive Scenario
7.2.3.3. Regulatory Framework
7.2.3.4. Target Disease Prevalence
7.2.3.5. Canada MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3. Europe
7.3.1. Europe MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.2. UK
7.3.2.1. Key Country Dynamics
7.3.2.2. Competitive Scenario
7.3.2.3. Regulatory Framework
7.3.2.4. Target Disease Prevalence
7.3.2.5. UK MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.3. Germany
7.3.3.1. Key Country Dynamics
7.3.3.2. Competitive Scenario
7.3.3.3. Regulatory Framework
7.3.3.4. Target Disease Prevalence
7.3.3.5. Germany MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.4. Spain
7.3.4.1. Key Country Dynamics
7.3.4.2. Competitive Scenario
7.3.4.3. Regulatory Framework
7.3.4.4. Target Disease Prevalence
7.3.4.5. Spain MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.5. France
7.3.5.1. Key Country Dynamics
7.3.5.2. Competitive Scenario
7.3.5.3. Regulatory Framework
7.3.5.4. Target Disease Prevalence
7.3.5.5. France MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.6. Italy
7.3.6.1. Key Country Dynamics
7.3.6.2. Competitive Scenario
7.3.6.3. Regulatory Framework
7.3.6.4. Target Disease Prevalence
7.3.6.5. Italy MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.7. Denmark
7.3.7.1. Key Country Dynamics
7.3.7.2. Competitive Scenario
7.3.7.3. Regulatory Framework
7.3.7.4. Target Disease Prevalence
7.3.7.5. Denmark Microrna (Mirna) Market, 2018 – 2030 (USD Million)
7.3.8. Sweden
7.3.8.1. Key Country Dynamics
7.3.8.2. Competitive Scenario
7.3.8.3. Regulatory Framework
7.3.8.4. Target Disease Prevalence
7.3.8.5. Sweden MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.3.9. Norway
7.3.9.1. Key Country Dynamics
7.3.9.2. Competitive Scenario
7.3.9.3. Regulatory Framework
7.3.9.4. Target Disease Prevalence
7.3.9.5. Norway MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4. Asia Pacific
7.4.1. Asia-Pacific MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.2. Japan
7.4.2.1. Key Country Dynamics
7.4.2.2. Competitive Scenario
7.4.2.3. Regulatory Framework
7.4.2.4. Target Disease Prevalence
7.4.2.5. Japan MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.3. China
7.4.3.1. Key Country Dynamics
7.4.3.2. Competitive Scenario
7.4.3.3. Regulatory Framework
7.4.3.4. Target Disease Prevalence
7.4.3.5. China MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.4. India
7.4.4.1. Key Country Dynamics
7.4.4.2. Competitive Scenario
7.4.4.3. Regulatory Framework
7.4.4.4. Target Disease Prevalence
7.4.4.5. India MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.5. South Korea
7.4.5.1. Key Country Dynamics
7.4.5.2. Competitive Scenario
7.4.5.3. Regulatory Framework
7.4.5.4. Target Disease Prevalence
7.4.5.5. South Korea MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.6. Thailand
7.4.6.1. Key Country Dynamics
7.4.6.2. Competitive Scenario
7.4.6.3. Regulatory Framework
7.4.6.4. Target Disease Prevalence
7.4.6.5. Thailand MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.4.7. Australia
7.4.7.1. Key Country Dynamics
7.4.7.2. Competitive Scenario
7.4.7.3. Regulatory Framework
7.4.7.4. Target Disease Prevalence
7.4.7.5. Australia MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.5. Latin America
7.5.1. Latin America MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.5.2. Brazil
7.5.2.1. Key Country Dynamics
7.5.2.2. Competitive Scenario
7.5.2.3. Regulatory Framework
7.5.2.4. Target Disease Prevalence
7.5.2.5. Brazil MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.5.3. Mexico
7.5.3.1. Key Country Dynamics
7.5.3.2. Competitive Scenario
7.5.3.3. Regulatory Framework
7.5.3.4. Target Disease Prevalence
7.5.3.5. Mexico MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.5.4. Argentina
7.5.4.1. Key Country Dynamics
7.5.4.2. Competitive Scenario
7.5.4.3. Regulatory Framework
7.5.4.4. Target Disease Prevalence
7.5.4.5. Argentina MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.6. MEA
7.6.1. MEA MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.6.2. South Africa
7.6.2.1. Key Country Dynamics
7.6.2.2. Competitive Scenario
7.6.2.3. Regulatory Framework
7.6.2.4. Target Disease Prevalence
7.6.2.5. South Africa MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.6.3. Saudi Arabia
7.6.3.1. Key Country Dynamics
7.6.3.2. Competitive Scenario
7.6.3.3. Regulatory Framework
7.6.3.4. Target Disease Prevalence
7.6.3.5. Saudi Arabia MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.6.4. UAE
7.6.4.1. Key Country Dynamics
7.6.4.2. Competitive Scenario
7.6.4.3. Regulatory Framework
7.6.4.4. Target Disease Prevalence
7.6.4.5. UAE MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
7.6.5. Kuwait
7.6.5.1. Key Country Dynamics
7.6.5.2. Competitive Scenario
7.6.5.3. Regulatory Framework
7.6.5.4. Target Disease Prevalence
7.6.5.5. Kuwait MicroRNA (miRNA) Market, 2018 – 2030 (USD Million)
Chapter 8. Competitive Landscape
8.1. Company Categorization
8.2. Strategy Mapping
8.2.1. Acquisition
8.2.2. Product/Service Launch
8.2.3. Partnerships/Collaborations
8.2.4. Others
8.3. Market Position Analysis, 2023
8.4. Company Profiles
8.4.1. Thermo Fisher Scientififc, Inc
8.4.1.1. Company Overview
8.4.1.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.1.3. Product Benchmarking
8.4.1.4. Strategic Initiatives
8.4.2. QIAGEN
8.4.2.1. Company Overview
8.4.2.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.2.3. Product Benchmarking
8.4.2.4. Strategic Initiatives
8.4.3. Horizon Discovery Group Co.
8.4.3.1. Company Overview
8.4.3.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.3.3. Product Benchmarking
8.4.3.4. Strategic Initiatives
8.4.4. NanoString Technologies, Inc
8.4.4.1. Company Overview
8.4.4.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.4.3. Product Benchmarking
8.4.4.4. Strategic Initiatives
8.4.5. Merck KGaA
8.4.5.1. Company Overview
8.4.5.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.5.3. Product Benchmarking
8.4.5.4. Strategic Initiatives
8.4.6. Takara Bio, Inc
8.4.6.1. Company Overview
8.4.6.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.6.3. Product Benchmarking
8.4.6.4. Strategic Initiatives
8.4.7. LGC Limited
8.4.7.1. Company Overview
8.4.7.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.7.3. Product Benchmarking
8.4.7.4. Strategic Initiatives
8.4.8. BioGenex
8.4.8.1. Company Overview
8.4.8.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.8.3. Product Benchmarking
8.4.8.4. Strategic Initiatives
8.4.9. GeneCopoeia, Inc
8.4.9.1. Company Overview
8.4.9.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.9.3. Product Benchmarking
8.4.9.4. Strategic Initiatives
8.4.10. New England Biolabs
8.4.10.1. Company Overview
8.4.10.2. Financial Performance (Net Revenue/Sales/EBITDA/Gross Profit)
8.4.10.3. Product Benchmarking
8.4.10.4. Strategic Initiatives

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